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iDiagnostics - the handheld future of precision medicine; Single Molecule Detection, Single Cell Analysis,  Cell Membrane Studies, TIRF microscopy, TIRF accessories for fluorometers, TIRF biosensor instruments, Real-time TIRF microarrays, and more>>> visit  www.tirf-labs.com

Molecular iDiagnostics for Home Use

by TIRF Labs

www.tirf-labs.com

Mail: info@tirf-labs.com

Open Innovation Business Model

The scale of this project is very large; it is impossible for a single firm to address the numerous challenges. We envision collective global effort of scientists, engineers, businessmen, and administrators in the framework of open innovation business model. By the beginning of 2018, six research groups worldwide have already joined the iDiagnostics project. Several other groups have expressed their interest in joining. We would like to invite more research groups to join this global effort, and are planning to intensively advertise our efforts and provide comprehensive support to our collaborators.  

This project will be using the Open Innovation Business Model, which stimulates the exchange of Intellectual Property (IP) between collaborators. TIRF Labs will supply unique hardware, software, cartridge blanks, development tools, reagent kits, methods and protocols to our collaborators to help interface their existing bioassays with the iDiagnostics platform and develop new assays. TIRF Labs will be delighted to license the IP of our collaborators and will offer them the opportunity to license our IP (in certain instances free of charge) to develop precise, rapid, and still affordable devices for molecular diagnosis and prognosis.

  Biodetection Station uTIRF. The feedback that we have received from our first collaborators has inspired us to develop a versatile instrument, uTIRF Biodetection Station, which is designed for different tasks  at the development stage from biomarker discovery to clinical testing. There are dozens of other applications related to molecular diagnostics, biomarker discovery, elucidating the mechanisms of disease, routine clinical analyses, and even the measurement of chemical analytes, where the uTIRF Biodetection Station can be used for as well. uTIRF is sensitive down to single molecules and is easy to use for numerous lifescience applications.

The project will be performed in two phases. In Phase 1, TIRF Labs will supply the uTIRF Biodetection Station and iDiagnostics Application Development Kit (ADK) to other research groups that are working in the area of molecular diagnostics. The ADK and uTIRF will facilitate the initial stages of the diagnostic cycle, i.e. creating panels of biomarkers, assay development and validation, and clinical testing. In Phase 2, which will start in 18-24 months after the beginning of Phase 1, we will start manufacturing iDiagnostics devices and begin supplying them to all interested parties, including the general public. Applications for the iDiagnostics platform include the diagnosis and prognosis of cancer, heart diseases, infectious diseases, longevity studies, food and water safety, military, forensic, environmental, and agricultural applications, as well as disease prevention actions and counter-measures against bioterrorism and naturally occurring diseases. For more information contact us by email: info@tirf-labs.com.

   If you are developing a molecular diagnostics system based on fluorescence or electro-chemi-luminescence assays, we are offering to you an exciting opportunity to collaborate. We will help you with unique hardware, software, cartridge blanks, development tools, reagent kits, methods and protocols to facilitate the interfacing of your assays with advanced iDiagnostics platform. We will be delighted to license your Intellectual Property (IP) and offer you the opportunity to license our IP to develop precise and rapid, and yet affordable devices for molecular diagnosis and prognosis.  

  The iDiagnostics platform provides unprecedented precision and rapid diagnosing due to its superior sensitivity, multiplicity, and fast response rate. The platform is several orders of magnitude more sensitive and more accurate than traditional methods. One of the advantages of iDiagnostics involves simultaneous detection of multiple molecular markers of different classes, including proteins, nucleic acids, and metabolites. Detection of different classes of  markers is necessary for minimization of  the rate  of false positive responses.  

   iDiagnostics employs 3D-encapsulated real-time TIRF microarrays that include internal controls and standards for normalization and calibration, which provides high reliability and broad dynamic range to iDiagnostics analyses. The platform also supports other luminescence assays, including Electro-Chemi-Luminescence (ECL). iDiagnostics integrates optics, microfluidics, electronics, electrochemical system, and nanoengineered assays into a small handheld device.  Real-time TIRF microarrays are capable of parallel detecting up to thousands of analytes, including proteins, nucleic acids, toxins and chemical agents.

    iDiagnostics requires no or minimal sample preparation and can analyze complex biological fluids, including whole blood, saliva, and urine. It employs reagentless bioassays based on molecular beacons and sandwich-format antibody-based assays. Typically, molecular markers are detected in several  seconds or a few minutes after the sample is applied.

 Applications for the iDiagnostics platform include early diagnosing of cancer, heart diseases, STD, influenza, other infectious diseases, food and water safety, biodefense, forensic, military, environmental, and agricultural analyses.  

   Our goal is to make accurate iDiagnostics available to every one. Open Innovation Approach, which we use in this project, is well suited for collaborative development of advanced diagnostic products. If you are interested to become a part of this exciting project please send us an email to <info@tirf-labs.com>.

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