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iDiagnostics® for All

The Handheld Future of Precision Medicine

In collaboration

with TIRF Labs

www.tirf-labs.com

info@tirf-labs.com

919.463.9545

iDiagnostics Development Tools: uTIRF and ADK

Fig 1. iDiagnostics Application Development Kit (ADK) and ultimate TIRF biodetection station uTIRF. For more information click here and here

TIRF Labs is offering a family of products, tools, cartridge blanks, sample preparation modules, reagents, supplies, methods and protocols that facilitate all stages of innovations. TIRF Labs role is to provide logistics and service support of these innovations and to shorten their way to FDA approvals and application by end-users. In practice, the combination of ADK products and services facilitate interfacing of existing assays with iDiagnostics platform and stimulates the development  of new iDiagnostics applications. The main set of development products is shown in the Figure 1. uTIRF station is shown with prism-TIRF accessory installed, lightguide TIRF (lgTIRF) accessory is shown to the left from uTIRF. Cartridge blanks, manual microarrayer, and the handheld iDiagnostics cradle with cartridge blanks from the Application Development Kit are shown at the left. These products have already been successfully used by several our collaborators.

There are two unique features that set iDiagnostics apart from other molecular diagnostics technologies:

1) Real-time 3D TIRF microarray technology

This novel patent pending technology is what makes the handheld iDiagnostics device highly sensitive, multiplexed, precise, and rapid - while making it eligible for home use, allowing  costs of only ~$100 for the device and $1-3 for cartridges (applications). Click here to learn more about the iDiagnostics technology and here for the comparison with alternative technologies.

2)  Open Innovation Business Model (OIBM)

Open Innovation is integral part to creating the biological safety necessary for combating epidemics. As part of the OIBM, iDiagnostics offers tools and services to collaborators and partners for application development. These tools and services include: iDiagnostic products, methods, protocols, suppliers, tech support and other services that facilitate: a) interfacing of existing bioassays with the iDiagnostics platform and b) the development of novel assays and applications for iDiagnostics.

Fig. 1 shows the main components of the development tools: iDiagnostics Application Development Kit (ADK) and ultimate-TIRF (uTIRF) Biodetection Station. Fig. 2 illustrates the main stages of microarray printing, assaying and data acquisition and analysis.Left panel of Fig. 1 shows an early prototype of iDiagnostics and disposable cartridges.

Before the panels of assays are tested with iDiagnostics cartridges and the cradle, there are many stages of assay development, validation, calibration and other tasks that require rapid and direct assess to microarray. These development procedures are implemented using uTIRF station. For the development purposes uTIRF is equipped with open perfusion chambers. There are several formats of open perfusion and closed chambers for different development tasks. Open perfusion chambers are suitable for easy access to each individual spot of the panel. For more information about iDiagnostics ADK and uTIRF station refer to ADK and uTIRF pdf brochures and contact TIRF Labs via email: info@tirf-labs.com.




There are two unique peculiarities that set iDiagnostics project apart from the alternative molecular diagnostics efforts:  

1) Unique real-time 3D TIRF microarray technology - the handheld iDiagnostics for home use, which is highly sensitive, multiplexed, precise, rapid, and costs only ~$100 for device and $1-3 for cartridge. Click here to learn more about the iDiagnostics technology and here for the comparison with alternative technologies.

2)  Open Innovation Business Model is the second unique feature. This feature is of paramount importance for creating the biological safety infrastructure and for extending social network, which is necessary for combating epidemics. The OIBM involves use of a set of iDiagnostics development tools and services that enable collaborators and partners, who develop diagnostics applications, with respective products, methods, protocols, suppliers, tech support and services that facilitate interfacing of their existing bioassays with the iDiagnostics platform and cultivate the development of novel assays and applications for iDiagnostics.

Fig. 1 shows the main components of the development tools: iDiagnostics Application Development Kit (ADK) and ultimate-TIRF (uTIRF) Biodetection Station. Fig. 2 illustrates the main stages of microarray printing, assaying and data acquisition and analysis.

Before the panels of assays are tested with iDiagnostics cartridges and the cradle, there are many stages of assay development, validation, calibration and other tasks that require rapid and direct assess to microarray. These development procedures are implemented using uTIRF station. For the development purposes uTIRF is equipped with open perfusion chambers. There are several formats of open perfusion and closed chambers for different development tasks. Open perfusion chambers are suitable for easy access to each individual spot of the panel. For more information about iDiagnostics ADK and uTIRF station refer to ADK and uTIRF pdf brochures and contact TIRF Labs via email: info@tirf-labs.com.

 Several research groups worldwide have employed uTIRF biodetection station and iDiagnostics ADK for their studies. Distributing uTIRF-ADK and other development tools and methods, we will keep in mind that the ultimate goal of the iDiagnostics project is to create a decentralized precision diagnostics affordable for all. Fig. 1 shows an early prototype of iDiagnostics and disposable cartridges. In Phase 1, we plan to transform the first prototype into a robust iDiagnostics product well-suited for home use by minimally trained individuals. By the middle of Phase 2 we will have a well-refined iDiagnostics product ready for manufacturing.

Fig. 2: Printing iDiagnostics microarrays and using uTIRF biodetection station for real-time microarray data acquisition and analysis.